Flexible application of UV inactivated microorganisms!

UVC is called "deep ultraviolet" because it has a good effect on purification and disinfection. Although specific wavelengths affect different bonds within a biomolecule, both nucleotides and proteins can be modified by deep ultraviolet light. Therefore, microorganisms and biological materials can be inactivated as long as the appropriate amount of light is applied.
High-intensity UV LED technology delivers unparalleled depth UV irradiance that dramatically improves processes, including faster analysis and operation, and UV LED technology completely inactivates contaminants in minutes compared to traditional methods.
Today's article is to tell you why UV LED technology is worthy of research labs and production equipment to seriously consider inactivating biomolecules and microorganisms. What is the result of the study of Phoseon's inactivation to varying degrees? Knock on the blackboard, focus on the key, follow the small series and look down.
Intractable pollution like RNase A can be completely deactivated at the appropriate wavelength and UV intensity. UV LEDs complete the complete inactivation of laboratory contaminants in less than five minutes at a fraction of the cost of traditional methods.
UV LED technology provides a new approach to microbial inactivation. UVC or bactericidal UV has good disinfection properties and is ideal for sensitive surfaces in laboratories or equipment. UV LEDs inactivate microorganisms, surface disinfection without chemical residues and time consuming flushing.

LED technology inactivates RNase, especially RNase A, which is difficult to irreversibly inactivate in the absence of long-term heat treatment or irritating chemicals. Traditional inactivation methods may be incompatible with common laboratory materials or complicate subsequent biochemical reactions. Fast, complete and irreversible deactivation of RNase A with a mercury lamp source has been difficult to achieve because of the low power output of the wavelength and the need to filter out unwanted wavelengths that do not cause deactivation.
We report here that the high irradiance UV LED light engine is used to inactivate the enzyme. The results show that both irradiance (intensity) and radiant flux (dose) can rapidly inactivate RNase A enzyme. Ultraviolet light at 275 nm is believed to have an effect on the disulfide bond of the aromatic amino acid of RNase A. The 365 nm wavelength targets the lysine side chain and is designed to disrupt the stability of the RNase A reaction pocket. These two wavelengths work synergistically to rapidly deactivate RNase A. We believe that high intensity UV LED irradiation is a novel and fast method.
The contamination of Bacillus licheniformis is difficult to remove. In this study by Phoseon, high-intensity UV LEDs were used to rapidly process Clostridium spores that were difficult to remove.
Clostridium spores were inactivated within 30 seconds by a combination of 275 nm and 275 nm + 365 nm, driving a wavelength greater than 5 log (5.79 log) CFU for the protein disulfide bond. This is consistent with our findings that when RNaseA is irreversibly inactivated, there is a synergy between the 275 nm and 365 nm high intensity UV LEDs.
For decades, it has been recognized that ultraviolet light has the ability to inactivate biological molecules. However, complete deactivation of difficult targets such as enzymes and spore-forming microorganisms has exceeded the capabilities of conventional light sources. By targeting specific molecular bonds, UV LED technology has higher efficiency and lower total power consumption than broadband sources such as mercury. UV LED technology makes new methods and discoveries in research laboratories possible.
Phoseon is the first development led UV LED system up to 5W / cm2 at 275nm, significantly higher than other LED systems. This milestone has enabled users to take advantage of the UV LED system, and Phoseon is opening up a new path to improve process sterilization capabilities by building high-performance UV LED systems. The bactericidal level of LEDs is about to reach the bactericidal level of clinically relevant difficult pathogens.

In addition to high-performance decontamination and disinfection systems, exciting research is also being applied in other areas. Preliminary data indicate that high-intensity UV can partially or completely inactivate the virus without compromising the identification characteristics. In existing methods of virus inactivation, retaining the identification feature is a challenge. Please continue to follow our public number and we will promptly push relevant information.